UPF 1069
UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.
Product Specifications
CAS Number
[1048371-03-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UPF-1069.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O
Molecular Formula
C17H13NO3
Molecular Weight
279.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Pellicciari R, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3 (6) :914-23.|[2]Moroni F, et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Curated Selection
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