UBCS039
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].
Product Specifications
CAS Number
358721-70-7
Product Name Alternative
5-(4-Phenoxybutoxy)psoralen,ZM-211974
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Sirtuin
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ubcs039.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
Molecular Formula
C16H13N3
Molecular Weight
247.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Weijie You, et al. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. 2017, 56, 1007-1011.|[2]Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC432566 20 µg
C10orf105 (NM_001168390) Human Over-expression Lysate
Sign In for Pricing
View Details 
