UBCS039
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].
Product Specifications
CAS Number
[358721-70-7]
Product Name Alternative
5-(4-Phenoxybutoxy)psoralen,ZM-211974
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Sirtuin
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ubcs039.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
Molecular Formula
C16H13N3
Molecular Weight
247.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Weijie You, et al. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. 2017, 56, 1007-1011.|[2]Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6
Available Sizes
Curated Selection
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