AR-M 1000390 (hydrochloride)
AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.
Product Specifications
CAS Number
209808-47-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AR-M_1000390_hydrochloride.html
Concentration
10mM
Purity
98.20
Solubility
DMSO : ≥ 150 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N(CC)CC)C1=CC=C(/C(C2=CC=CC=C2)=C3CCNCC/3)C=C1.Cl
Molecular Formula
C23H29ClN2O
Molecular Weight
384.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei ZY, et al. N, N-Diethyl-4- (phenylpiperidin-4-ylidenemethyl) benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. J Med Chem. 2000 Oct 19;43 (21) :3895-905.|[2]Otieno MA, et al. Mechanistic investigation of N, N-diethyl-4- (phenyl-piperidin-4-ylidenemethyl) -benzamide-inducedinsulin depletion in the rat and RINm5F cells. Toxicol Sci. 2008 Sep;105 (1) :221-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR
Available Sizes
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