AR-M 1000390 (hydrochloride)

AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.

Product Specifications

CAS Number

[209808-47-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AR-M_1000390_hydrochloride.html

Concentration

10mM

Purity

98.20

Solubility

DMSO : ≥ 150 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N(CC)CC)C1=CC=C(/C(C2=CC=CC=C2)=C3CCNCC/3)C=C1.Cl

Molecular Formula

C23H29ClN2O

Molecular Weight

384.94

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei ZY, et al. N, N-Diethyl-4- (phenylpiperidin-4-ylidenemethyl) benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. J Med Chem. 2000 Oct 19;43 (21) :3895-905.|[2]Otieno MA, et al. Mechanistic investigation of N, N-diethyl-4- (phenyl-piperidin-4-ylidenemethyl) -benzamide-inducedinsulin depletion in the rat and RINm5F cells. Toxicol Sci. 2008 Sep;105 (1) :221-9.