Thapsigargin
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types[1][2][3][4][5].
Product Specifications
CAS Number
[67526-95-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H334, H335
Target
Apoptosis; Calcium Channel; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Thapsigargin.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCCCCCC(O[C@@H]1[C@@H](OC(/C(C)=C\C)=O)C(C)=C2[C@@]1([H])[C@@](C)(OC(C)=O)C[C@H](OC(CCC)=O)[C@@]([C@@]3(O)C)(O)[C@@]2([H])OC3=O)=O
Molecular Formula
C34H50O12
Molecular Weight
650.75
Precautions
H315, H319, H334, H335
References & Citations
2+
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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