BMS 695735

BMS 695735 (compound 10) is an inhibitor of IGF-1R with an IC50 value of 0.034 μM. BMS 695735 has anti-tumor activity[1].

Product Specifications

CAS Number

[1054315-48-8]

UNSPSC

12352005

Target

IGF-1R

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-695735.html

Smiles

O=C1C(C2=NC3=C(C)C=C(C4CCN(CCCF)CC4)C=C3N2)=C(NCCN5N=CC(Cl)=C5)C=CN1

Molecular Formula

C26H31ClFN7O

Molecular Weight

512.02

References & Citations

[1]Discovery and Evaluation of 4- (2- (4-chloro-1H-pyrazol-1-yl) ethylamino) -3- (6- (1- (3-fluoropropyl) piperidin-4-yl) -4-methyl-1H-benzo[d]imidazol-2-yl) pyridin-2 (1H) -one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity J. Med. Chem., 2008, 51 (19), pp 5897-5900