4,5-Dimethoxycanthin-6-one
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae) [1][2].
Product Specifications
CAS Number
[18110-87-7]
UNSPSC
12352005
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-5-dimethoxycanthin-6-one.html
Purity
98.68
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C(OC)=C1OC
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
References & Citations
[1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents|[2]Miao X, et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP1
Available Sizes
Curated Selection
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