PKG drug G1
PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
Product Specifications
CAS Number
374703-78-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PKG_drug_G1.html
Purity
99.11
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S
Molecular Formula
C13H11N3OS
Molecular Weight
257.31
Precautions
H302, H315, H319
References & Citations
[1]Burgoyne JR, et al. Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα) . Hypertension. 2017 Sep;70 (3) :577-586.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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