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PKG drug G1

PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

Product Specifications

CAS Number

374703-78-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/PKG_drug_G1.html

Purity

99.11

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S

Molecular Formula

C13H11N3OS

Molecular Weight

257.31

Precautions

H302, H315, H319

References & Citations

[1]Burgoyne JR, et al. Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα) . Hypertension. 2017 Sep;70 (3) :577-586.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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