Anti-Hu CD200R PE
CD200R is a transmembrane glycoprotein, expressed on the surface of myeloid cells. Its interaction with CD200 leads in these cells to a downregulatory signal. This interaction may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R gene results in multiple transcript variants. These isoforms may play a role in differentiation, e.g. regards tolerogenic dendritic cells. Besides myeloid cells, CD200R can be found also on a T cell subset.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant human CD200R
Target Antigen
CD200R
Clone
OX-108
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Choueiry F, Torok M, Shakya R, Agrawal K, Deems A, Benner B, Hinton A, Shaffer J, Blaser BW, Noonan AM, Williams TM, Dillhoff M, Conwell DL, Hart PA, Cruz-Monserrate Z, Bai XF, Carson WE, Mace TA: CD200 promotes immunosuppression in the pancreatic tumor microenvironment. J Immunother Cancer. 2020 Jun;8 (1) :e000189. , URL: https://pubmed.ncbi.nlm.nih.gov/32581043/, *Koning N, Swaab DF, Hoek RM, Huitinga I: Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J Neuropathol Exp Neurol. 2009 Feb;68 (2) :159-67., URL: https://pubmed.ncbi.nlm.nih.gov/19151626/, *Byrareddy SN, Little D, Mayne AE, Villinger F, Ansari AA: Phenotypic and functional characterization of monoclonal antibodies with specificity for rhesus macaque CD200, CD200R and mincle. PLoS One. 2015 Oct 15;10 (10) :e0140689. , URL: https://pubmed.ncbi.nlm.nih.gov/26468886/, *Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN: Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. J Virol. 2004 Jul;78 (14) :7667-76. , URL: https://pubmed.ncbi.nlm.nih.gov/15220441/, *Mihrshahi R, Barclay AN, Brown MH: Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol. 2009 Oct 15;183 (8) :4879-86. , URL: https://pubmed.ncbi.nlm.nih.gov/19786546/, *Misstear K, Chanas SA, Rezaee SA, Colman R, Quinn LL, Long HM, Goodyear O, Lord JM, Hislop AD, Blackbourn DJ: Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200. J Virol. 2012 Jun;86 (11) :6246-57. , URL: https://pubmed.ncbi.nlm.nih.gov/22491458/, *Letarte M, Voulgaraki D, Hatherley D, Foster-Cuevas M, Saunders NJ, Barclay AN: Analysis of leukocyte membrane protein interactions using protein microarrays. BMC Biochem. 2005 Mar 1;6:2. doi: 10.1186/1471-2091-6-2. , URL: https://pubmed.ncbi.nlm.nih.gov/15740616/, *Fellermeyer M, Anzilotti C, Paluch C, Cornall RJ, Davis SJ, Gileadi U: Combination CD200R/PD-1 blockade in a humanised mouse model. Immunother Adv. 2023 Mar 30;3 (1) :ltad006. , URL: https://pubmed.ncbi.nlm.nih.gov/37082107/, *Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN: Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol. 2003 Sep 15;171 (6) :3034-46., URL: https://pubmed.ncbi.nlm.nih.gov/12960329/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody OX-108 recognizes an extracellular epitope on human CD200R, a transmembrane flycoprotein expressed on the surface of myeloid cells.
Applications Notes
6
Isotype
Mouse IgG1 kappa
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