Mps1-IN-7

Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50= 0.11 μM, JNK2 IC50=0.22 μM) . Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM, respectively[1].

Product Specifications

CAS Number

[1578244-34-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mps1-in-7.html

Purity

98.55

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(C)(C)[C@@H](NC1=NC=CC2=CN=C(NC3=CC=C(C4=CN(C)N=C4)C=C3OC)N=C21)C

Molecular Formula

C24H29N7O

Molecular Weight

431.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Paolo Innocenti, et al. Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. J Med Chem. 2016 Apr 28;59 (8) :3671-88