JY-2

JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1].

Product Specifications

CAS Number

[339103-05-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

FOXO

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jy-2.html

Concentration

10mM

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC(Cl)=C(C2=NC(C3=CC=CC=N3)=NO2)C=C1

Molecular Formula

C13H7Cl2N3O

Molecular Weight

292.12

Precautions

H302, H315, H319

References & Citations

[1]Choi HE, et al. Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model. Eur J Pharmacol. 2021 May 15;899:174011.