4-Methyldaphnetin

4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].

Product Specifications

CAS Number

[2107-77-9]

UNSPSC

12352005

Hazard Statement

H319, H334

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-methyldaphnetin.html

Purity

99.40

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1C=C(C)C2=CC=C(O)C(O)=C2O1

Molecular Formula

C10H8O4

Molecular Weight

192.17

Precautions

H319, H334

References & Citations

[1]Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21 (Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86 (2) :210-21.|[2]Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27 (3) :268-74.|[3]Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7 (9) :2091-4.