VUF 8430 (dihydrobromide)
VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].
Product Specifications
CAS Number
[100130-32-3]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vuf-8430-dihydrobromide.html
Purity
98.00
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
N=C(N)SCCNC(N)=N.[H]Br.[H]Br
Molecular Formula
C4H13Br2N5S
Molecular Weight
323.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Lim HD, et al. Discovery of S- (2-guanidylethyl) -isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49 (23) :6650-1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Curated Selection
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