Bis-propargyl-PEG2

Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[126422-57-9]

UNSPSC

12352211

Hazard Statement

H227

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bis-propargyl-peg2.html

Purity

98.08

Solubility

10 mM in DMSO

Smiles

C#CCOCCOCCOCC#C

Molecular Formula

C10H14O3

Molecular Weight

182.22

Precautions

H227

References & Citations

[1]Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13 (10) :3018-30.|[2]Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74 (27), 3527–3533.