ISRIB (trans-isomer)
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM) .
Product Specifications
CAS Number
1597403-47-8
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; PERK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ISRIB-trans-isomer.html
Purity
99.49
Solubility
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
Molecular Formula
C22H24Cl2N2O4
Molecular Weight
451.34
Precautions
H302
References & Citations
[1]Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498.|[2]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP318101M 100 µg
MEK3 (MAP2K3) (NM_002756) Human Recombinant Protein
Sign In for Pricing
View Details 