ISRIB (trans-isomer)

ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM) .

Product Specifications

CAS Number

[1597403-47-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; PERK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ISRIB-trans-isomer.html

Purity

99.49

Solubility

DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3

Molecular Formula

C22H24Cl2N2O4

Molecular Weight

451.34

Precautions

H302

References & Citations

[1]Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498.|[2]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.