MSI-1436 lactate
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM) .
Product Specifications
CAS Number
1309370-86-2
Product Name Alternative
Trodusquemine lactate; Aminosterol-1436 lactate
UNSPSC
12352211
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/MSI-1436_lactate.html
Purity
98.79
Solubility
0.1 M HCl : 50 mg/mL (ultrasonic; adjust pH to 4 with HCl) |DMSO : 54 mg/mL (ultrasonic; warming)
Smiles
NCCCNCCCCNCCCN[C@@H]1C[C@@](C[C@@H](O)[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@]4([C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)[H])([H])[C@]3(C)CC1.O=C(O)C(C)O.[3.5]
Molecular Formula
C37H72N4O5S.7/2C3H6O3
Molecular Weight
1000.17
References & Citations
[1]Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring) . 2010 Aug;18 (8) :1516-1523.|[2]Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85 (6) :1319-31.|[3]Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458 (1) :21-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Citation 01
Commun Biol. 2021 Feb 24;4 (1) :248.|J Ginseng Res. 2025 Sep 2.|Nature. 2024 Jul;631 (8020) :415-423.|Oncol Rep. 2024 Nov;52 (5) :149.|Exp Neurol. 2025 Mar:385:115115.|J Leukoc Biol. 2024 Jul 16:qiae159.|Spectrochim Acta A Mol Biomol Spectrosc. 2024 Nov 3:327:125394.
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