MSI-1436 lactate

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM) .

Product Specifications

CAS Number

[1309370-86-2]

Product Name Alternative

Trodusquemine lactate; Aminosterol-1436 lactate

UNSPSC

12352211

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/MSI-1436_lactate.html

Purity

98.79

Solubility

0.1 M HCl : 50 mg/mL (ultrasonic; adjust pH to 4 with HCl) |DMSO : 54 mg/mL (ultrasonic; warming)

Smiles

NCCCNCCCCNCCCN[C@@H]1C[C@@](C[C@@H](O)[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@]4([C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)[H])([H])[C@]3(C)CC1.O=C(O)C(C)O.[3.5]

Molecular Formula

C37H72N4O5S.7/2C3H6O3

Molecular Weight

1000.17

References & Citations

[1]Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring) . 2010 Aug;18 (8) :1516-1523.|[2]Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85 (6) :1319-31.|[3]Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458 (1) :21-7.