Phen-DC3 Trifluoromethanesulfonate

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

Product Specifications

CAS Number

[929895-45-4]

Product Name Alternative

Phen-DC3 Triflate

UNSPSC

12352005

Target

G-quadruplex

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Phen-DC3_Trifluoromethanesulfonate.html

Purity

99.09

Solubility

DMSO : ≥ 34 mg/mL

Smiles

[O-]S(=O)(C(F)(F)F)=O.C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1.[O-]S(=O)(C(F)(F)F)=O

Molecular Formula

C36H26F6N6O8S2

Molecular Weight

848.75

References & Citations

[1]Sanjay Kumar Bharti, et al. Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability. J Biol Chem. 2013 Sep 27; 288 (39) : 28217–28229.|[2]Aurèle Piazza, et al. Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J. 2015 Jun 12; 34 (12) : 1718–1734.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Cell Death Dis. 2021 Oct 25;12 (11) :999.|Int J Biol Macromol. 2025 Jan 9:139582.|Int J Biol Macromol. 2025 Jun 20;319 (Pt 1) :145405.|iScience. 2022 Oct 9;25 (11) :105312.|J Phys Chem B. 2023 Jul 6;127 (26) :5859-5868.|Nucleic Acids Res. 2024 Mar 21;52 (5) :2142-2156.|Patent. US20210188889A1.