TL13-12
TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) [1].
Product Specifications
CAS Number
[2229037-04-9]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tl13-12.html
Concentration
10mM
Purity
98.16
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
Molecular Formula
C45H53ClN10O10S
Molecular Weight
961.48
References & Citations
[1]Powell CE, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) .J Med Chem. 2018 May 10;61 (9) :4249-4255.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
