TGR5 Receptor Agonist 4

TGR5 Receptor Agonist 4 is an agonist of Bile Acid Receptor (TGR5), with EC50 for hTGR5 and mTGR5 of 2 nM and 3 nM, respectively. TGR5 Receptor Agonist 4 plays important roles in hypoglycemic and weight loss[1].

Product Specifications

CAS Number

[1872436-42-4]

UNSPSC

12352005

Target

G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tgr5-receptor-agonist-4.html

Purity

98.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=CC=C1)=C1COC(C([C@H](C2=CN=C(Cl)C=C2)C3)=C(C)N(C[C@H]4CCCO4)C3=O)=O

Molecular Formula

C25H27ClN2O5

Molecular Weight

470.95

References & Citations

[1]Sylvain Picon, et al. Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5. J Med Chem. 2023 Sep 14;66 (17) :11732-11760.