Stiripentol
Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively.
Product Specifications
CAS Number
[49763-96-4]
Product Name Alternative
BCX2600
UNSPSC
12352005
Hazard Statement
H302
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Stiripentol.html
Purity
99.99
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1
Molecular Formula
C14H18O3
Molecular Weight
234.29
Precautions
H302
References & Citations
[1]Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34 (4) :608-11. Epub 2006 Jan 13.|[2]Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53 (7) :1140-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP2; CYP3
Available Sizes
Curated Selection
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