Miquelianin

Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

Product Specifications

CAS Number

[22688-79-5]

Product Name Alternative

Quercetin 3-O-glucuronide; Quercetin 3-glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Miquelianin.html

Purity

99.96

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O

Molecular Formula

C21H18O13

Molecular Weight

478.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Terao J, e al. Protection by quercetin and quercetin 3-O-beta-D-glucuronide of peroxynitrite-induced antioxidant consumption in human plasma low-density lipoprotein. Free Radic Res. 2001 Dec;35 (6) :925-31.|[2]Juergenliemk G, et al. In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Med. 2003 Nov;69 (11) :1013-7.|[3]Butterweck V, et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med. 2000 Feb;66 (1) :3-6.|[4]Yamazaki S, et al. Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking β-adrenergic signaling. Arch Biochem Biophys. 2014 Sep 1;557:18-27.|[5]Ho L, et al. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. FASEB J. 2013 Feb;27 (2) :769-81.|[6]Iannuzzi A M, et al. Chemical profile and nutraceutical features of Salsola soda (agretti) : Anti-inflammatory and antidiabetic potential of its flavonoids[J]. Food Bioscience, 2020, 37: 100713.