Z-Gly-Gly-Arg-AMC (acetate)
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) [1][2].
Product Specifications
CAS Number
2070009-61-7
UNSPSC
12171500
Target
Fluorescent Dye; Thrombin
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Z-Gly-Gly-Arg-AMC-acetate.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20 mg/mL (ultrasonic)
Smiles
CC(O)=O.O=C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)=O)=O)OCC3=CC=CC=C3
Molecular Formula
C30H37N7O9
Molecular Weight
639.66
References & Citations
[1]Tarandovskiy ID, et al. Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. PLoS One. 2013;8 (2) :e55688.|[2]Machlus KR, et al. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov;102 (5) :936-44.|[3]Mothukuri GK, et al. Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries. Chem Sci. 2020 Jun 26;11 (30) :7858-7863.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Citation 01
Acta Pharmacol Sin. 2024 Nov;45 (11) :2300-2312.|Bioorg Chem. 2019 Nov:92:103199.|Blood Adv. 2025 Mar 24:bloodadvances.2024015212.|Cell Rep Med. 2025 Aug 19;6 (8) :102260.|Chem Biol Interact. 2023 Jun 1:378:110501.|J Mater Chem B. 2017 Oct 14;5 (38) :7876-7884. |RSC Adv. 2020, 10 (7) :3626-3635.|Spectrochim Acta A Mol Biomol Spectrosc. 2022 Jan 5:264:120250.|Int J Biol Macromol. 2019 Aug 1:134:622-630.|Int J Biol Macromol. 2019 Sep 15:137:261-269.|Phytochemistry. 2019 Sep:165:112025.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC742216-500 1x 500 µL
CD50 / ICAM3 (CG106), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740257-100 1x 100 µL
Cytokeratin, HMW (AE-3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880460-100 1x 100 µL
CD44 Standard (156-3C11), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
