PPGB (20k, Cleaved-Met327) rabbit pAb

Catalytic activity: Release of a C-terminal amino acid with broad specificity. Disease: Defects in CTSA are the cause of galactosialidosis [MIM: 256540]. It is an autosomal recessive disease. function: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. similarity: Belongs to the peptidase S10 family. subunit: Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.

Product Specifications

Background

Catalytic activity:Release of a C-terminal amino acid with broad specificity., disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease., function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins., similarity:Belongs to the peptidase S10 family., subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.

UniProt

P10619

Swiss Prot

P10619

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human PPGB (20k, Cleaved-Met327)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

20 52kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

20 52kD

Fragment

IgG

Subcellular Location

Lysosome.

Other Product Names

Lysosomal protective protein (EC 3.4.16.5; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]