Pilocarpine (nitrate)
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
Product Specifications
CAS Number
148-72-1
UNSPSC
12352005
Hazard Statement
H301
Target
MAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Pilocarpine-nitrate.html
Purity
99.87
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
[O-][N+](O)=O.O=C1OC[C@H](CC2=CN=CN2C)[C@@H]1CC
Molecular Formula
C11H17N3O5
Molecular Weight
271.27
Precautions
H301
References & Citations
[1]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8 (1) :85-93.|[2]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9 (4) :505-11.|[3]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112 (2) :525-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
MAChR3
Available Sizes
Frequently Asked Questions
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