Pilocarpine (nitrate)

Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Product Specifications

CAS Number

[148-72-1]

UNSPSC

12352005

Hazard Statement

H301

Target

MAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Pilocarpine-nitrate.html

Purity

99.87

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

[O-][N+](O)=O.O=C1OC[C@H](CC2=CN=CN2C)[C@@H]1CC

Molecular Formula

C11H17N3O5

Molecular Weight

271.27

Precautions

H301

References & Citations

[1]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8 (1) :85-93.|[2]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9 (4) :505-11.|[3]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112 (2) :525-32.