EGFR/ErbB-2/ErbB-4 inhibitor-2
EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].
Product Specifications
CAS Number
179248-61-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-erbb-2-erbb-4-inhibitor-2.html
Concentration
10mM
Purity
99.45
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC1=CC2=NC=NC(NC3=CC=C(OCC4=CC=CC=C4)C=C3)=C2C=C1OC
Molecular Formula
C23H21N3O3
Molecular Weight
387.43
Precautions
H302, H315, H319
References & Citations
[1]Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277 (2) :1576-85.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4
Available Sizes
Frequently Asked Questions
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