Eprodisate (70% in water)

Eprodisate (70% in water) is an amyloid inhibitor that interferes with the interaction between amyloidogenic proteins and glycosaminoglycans, thereby inhibiting the aggregation of amyloid fibrils and the deposition of fibrils in tissues. Eprodisate (70% in water) slows the progression of renal disease associated with AA amyloidosis and may be useful for other types of amyloidosis[1][2][3].

Product Specifications

CAS Number

[21668-77-9]

UNSPSC

12352100

Hazard Statement

H314

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/eprodisate.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=S(CCCS(=O)(O)=O)(O)=O

Molecular Formula

C3H8O6S2

Molecular Weight

204.22

Precautions

H314

References & Citations

[1]Dember LM, et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356 (23) :2349-60.|[2]Manenti L, et al. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9 (12) :2175-80.|[3]Quaranta DV, et al. Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation. J Pharmacol Exp Ther. 2023 Jan;384 (1) :205-223.