XJB-5-131

XJB-5-131 is a mitochondria-targeted ROS and electron scavenger[1]. XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria[2]. XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs) [3].

Product Specifications

CAS Number

[866404-31-1]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xjb-5-131.html

Purity

99.9

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C)(C)OC(N[C@@H](CC(C)C)/C=C/[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(OCC3=CC=CC=C3)=O)C(NC4CC(C)(N(O)C(C)(C4)C)C)=O)=O)=O)=O)=O

Molecular Formula

C53H81N7O9

Molecular Weight

960.25

References & Citations

[1]Carlos A Macias, et al. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg. 2007 Feb;245 (2) :305-14.|[2]Zhiyin Xun, et al. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29;2 (5) :1137-42.|[3]Julie P Goff, et al. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Exp Hematol. 2013 Nov;41 (11) :957-66.