SJFα
SJFα is a selective p38α PROTAC degrader with a DC50 of 7.16 nM and Dmax of 97.4%. SJFα is far less effective at degrading p38δ (DC50 = 299 nM) . SJFαcan be used for the research of cancer, such as breast cancer[1]. (Structure Note: Pink: p38α ligand (HY-45124) ; Blue: VHL ligand (HY-125845) )
Product Specifications
CAS Number
[2254609-27-1]
UNSPSC
12352005
Target
P38 MAPK; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJF_alpha_.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
Molecular Formula
C59H67F2N7O11S
Molecular Weight
1120.27
References & Citations
[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10 (1) :131.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; p38δ; von Hippel-Lindau (VHL)
Available Sizes
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