SJFα
Product Specifications
UNSPSC Description
SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
Target Antigen
Autophagy; p38 MAPK; PROTACs
Type
Reference compound
Related Pathways
Autophagy;MAPK/ERK Pathway;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJF_alpha_.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
Molecular Weight
1120.27
References & Citations
[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114404/SJFα-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114404/SJFα-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2254609-27-1
Available Sizes
Curated Selection
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