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SJFα

SJFα is a selective p38α PROTAC degrader with a DC50 of 7.16 nM and Dmax of 97.4%. SJFα is far less effective at degrading p38δ (DC50 = 299 nM) . SJFαcan be used for the research of cancer, such as breast cancer[1]. (Structure Note: Pink: p38α ligand (HY-45124) ; Blue: VHL ligand (HY-125845) )

Product Specifications

CAS Number

[2254609-27-1]

UNSPSC

12352005

Target

P38 MAPK; PROTACs

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SJF_alpha_.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1

Molecular Formula

C59H67F2N7O11S

Molecular Weight

1120.27

References & Citations

[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10 (1) :131.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P38α; p38δ; von Hippel-Lindau (VHL)

Available Sizes

Curated Selection

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