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Levonadifloxacin

Levonadifloxacin ((S) - (-) -Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin -susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes[1].

Product Specifications

CAS Number

154357-42-3

Product Name Alternative

(S) - (-) -Nadifloxacin; WCK 771

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/levonadifloxacin.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CN2[C@@H](C)CCC3=C2C(C1=O)=CC(F)=C3N4CCC(O)CC4)O

Molecular Formula

C19H21FN2O4

Molecular Weight

360.38

Precautions

H301

References & Citations

[1]Dubois J, et al. Levonadifloxacin (WCK 771) exerts potent intracellular activity against Staphylococcus aureus in THP-1 monocytes at clinically relevant concentrations. J Med Microbiol. 2019 Dec;68 (12) :1716-1722. |[2]Bhagwat SS, et al. In Vivo Pharmacokinetic/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model. Antimicrob Agents Chemother. 2019 Jul 25;63 (8) :e00909-19.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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