SJ45566
SJ45566 a potent and orally active PROTAC-based LCK degrader, with a DC50 of 1.21 nM. SJ45566 can be used in the research for T‑Cell Acute Lymphoblastic Leukemia[1].
Product Specifications
CAS Number
3081937-95-0
UNSPSC
12352211
Target
PROTACs; Src
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj45566.html
Smiles
O=C(NC1=C(Cl)C=CC=C1C)C(S2)=CN=C2NC3=CC(N4CCC(CN5CCN(C6=CC=C(C7CCC(NC7=O)=O)C=C6)CC5)CC4)=NC(C)=N3
Molecular Formula
C37H42ClN9O3S
Molecular Weight
728.31
References & Citations
[1]Jamie A Jarusiewicz, et al. Development of an Orally Bioavailable LCK PROTAC Degrader as a Potential Therapeutic Approach to T-Cell Acute Lymphoblastic Leukemia. J Med Chem. 2024 Jul 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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