JX401
JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].
Product Specifications
CAS Number
349087-34-9
UNSPSC
12352005
Hazard Statement
H410
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jx401.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(SC)C=C1OC)N2CCC(CC3=CC=CC=C3)CC2
Molecular Formula
C21H25NO2S
Molecular Weight
355.49
Precautions
P273-P391-P501
References & Citations
[1]Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70 (4) :1395-1405.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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