JX401

JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

Product Specifications

CAS Number

[349087-34-9]

UNSPSC

12352005

Hazard Statement

H410

Target

P38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jx401.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(SC)C=C1OC)N2CCC(CC3=CC=CC=C3)CC2

Molecular Formula

C21H25NO2S

Molecular Weight

355.49

Precautions

P273-P391-P501

References & Citations

[1]Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70 (4) :1395-1405.