DDR1/2 inhibitor-2
DDR1/2 inhibitor-2 (Example 31) is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM. DDR1/2 inhibitor-2 can be used for research of cancer and fibrotic diseases[1].
Product Specifications
CAS Number
[2908756-11-4]
UNSPSC
12352005
Target
Discoidin Domain Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ddr1-2-inhibitor-2.html
Purity
99.73
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CN1C=CC2=C(C1=O)C(NC3=CC(C=NN4C)=C4C=C3)=CC=C2)NC5=CN=CC(C(F)(F)F)=C5
Molecular Formula
C25H19F3N6O2
Molecular Weight
492.45
References & Citations
[1]Inder Bhamra, et al. Phenyl- and pyridopyrazole derivatives as inhibitors of ddr1. Patent. WO2023021278.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1; DDR2
Available Sizes
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