CP-31398 (dihydrochloride)
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53[1][2][3].
Product Specifications
CAS Number
1217195-61-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-31398-dihydrochloride.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1.[H]Cl.[H]Cl
Molecular Formula
C22H28Cl2N4O
Molecular Weight
435.39
Precautions
H302, H315, H319, H335
References & Citations
[1]B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286 (5449) :2507-10.|[2]Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1 (1) :47-55.|[3]J Wischhusen, et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003 Nov 13;22 (51) :8233-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS8100112-01 25 Tests
Anti-VEGFR2/KDR Antibody (FITC), Mouse Monoclonal
Sign In for Pricing
View Details MBS8100112-02 100 Tests
Anti-VEGFR2/KDR Antibody (FITC), Mouse Monoclonal
Sign In for Pricing
View Details MBS8100112-03 5x 100 Tests
Anti-VEGFR2/KDR Antibody (FITC), Mouse Monoclonal
Sign In for Pricing
View Details 