CP-31398 (dihydrochloride)
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53[1][2][3].
Product Specifications
CAS Number
1217195-61-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-31398-dihydrochloride.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1.[H]Cl.[H]Cl
Molecular Formula
C22H28Cl2N4O
Molecular Weight
435.39
Precautions
H302, H315, H319, H335
References & Citations
[1]B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286 (5449) :2507-10.|[2]Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1 (1) :47-55.|[3]J Wischhusen, et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003 Nov 13;22 (51) :8233-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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