PF-562271 (besylate)
Product Specifications
UNSPSC Description
PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively[1].
Target Antigen
FAK; Pyk2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-562271-besylate.html
Purity
99.17
Solubility
DMSO : 21.4 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O
Molecular Weight
665.66
References & Citations
[1]Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.|[2]Lim ST, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7(15), 2306-2314.|[3]Canel M, et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res, 2010, 70(22), 9413-9422.Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Anticancer Drugs. 2023 Jul 14.|Breast Cancer Res. 2024 Mar 19;26(1):48.|Cancer Res. 2013 May 1;73(9):2873-83.|Carbohydr Polym. 2024 Feb 15, 326, 121637.|Cell Death Dis. 2022 Sep 10;13(9):783.|Cell Death Dis. 2023 Feb 24;14(2):157.|Cell Discov. 2022 Sep 6;8(1):84.|Cell Rep. 2023 Oct 5;42(10):113213.|Clin Cancer Res. 2019 Jul 15;25(14):4552-4566.|Environ Toxicol Pharmacol. 2023 Oct 20:104301.|Eur J Cell Biol. 2024 May 28;103(2):151427.|Harvard Medical School LINCS LIBRARY|Int J Cancer. 2015 Oct 1;137(7):1549-59.|J Nat Med. 2020 Sep;74(4):732-740.|Life Sci. 2021 Jan 25;119112.|Practical Oncology Journal. 2015, 29(5): 444-449.|Research Square Preprint. 2021 Dec.|Research Square Preprint. 2023 May 23.|Sci Rep. 2018 May 8;8(1):7228.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10458/PF-562271-besylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10458/PF-562271-besylate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
939791-38-5
Available Sizes
Curated Selection
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