Human LYPD1 / PHTS Protein, Mouse IgG2a Fc Tag (MALS verified)

Human LYPD1 Protein, Mouse IgG2a Fc Tag (LY1-H5258) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Gly 115 (Accession # Q8N2G4-1).

Product Specifications

Background

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.

Specifications

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 43-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Leu 21 - Gly 115

Host

HEK 293

Target

LYPD1

Conjugation

Unconjugated

Tag

C-mFc(mIgG2a)

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Bioactivity

Immobilized Human LYPD1 Protein, Mouse IgG2a Fc Tag (Cat. No. LY1-H5258) at 1 μg/mL (100 μL/well) can bind Anti-LYPD1 antibody with a linear range of 0.02-0.625 μg/mL (QC tested).