Biotin-PEG-azide (MW 1000)

Biotin-PEG-azide (MW 1000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[956494-20-5]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/biotin-peg-azide-mw-1000.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCCNC(CCCCC1SCC2NC(NC12)=O)=O.[n].[MW1000]

Molecular Weight

1000 (Average)

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.