Emedastine (difumarate)

Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis[1][2][3].

Product Specifications

CAS Number

[87233-62-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/emedastine-difumarate.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(C2=NC3=CC=CC=C3N2CCOCC)CCC1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O

Molecular Formula

C25H34N4O9

Molecular Weight

534.56

Precautions

P264-P270-P330-P501

References & Citations

[1]Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10 (4) :653-64.|[2]Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10 (11) :1859-67.|[3]Andoh T, et al. Involvement of blockade of leukotriene B (4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406 (1) :149-52.