IMB-XH1

IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) [1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively[2].

Product Specifications

CAS Number

[292057-76-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial; Bcl-2 Family; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Mcl1-IN-2.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

OC1=C(N=CC=C2)C2=CC=C1C(NC3=CC=CC=N3)C4=CC=CS4

Molecular Formula

C19H15N3OS

Molecular Weight

333.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21 (21) :6642-9.|[2]Jiangxue Han, et al. IMB-XH1 identified as a novel inhibitor of New Delhi metallo-β-lactamase-1.