L-Sepiapterin
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4) . L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia[1][2].
Product Specifications
CAS Number
[17094-01-8]
Product Name Alternative
Sepiapterin
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-sepiapterin.html
Purity
99.50
Solubility
DMSO : 10 mg/mL (ultrasonic;warming)
Smiles
O=C1NC(N)=NC2=C1N=C(C([C@@H](O)C)=O)CN2
Molecular Formula
C9H11N5O3
Molecular Weight
237.22
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Available Sizes
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KCNK1, CT (KCNK1, HOHO1, KCNO1, TWIK1, Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1, Potassium channel KCNO1) (PE)