L-770644 (dihydrochloride)
L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM) [1].
Product Specifications
CAS Number
[182251-68-9]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l-770644-dihydrochloride.html
Smiles
O=C1N(C2=CC=C(C=C2)S(NC3=CC=C(C=C3)CCNC[C@@H](C4=CN=CC=C4)O)(=O)=O)N=NN1CCCC5CCCC5.Cl.Cl
Molecular Formula
C30H39Cl2N7O4S
Molecular Weight
664.65
References & Citations
[1]Shih TL, et al. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9 (9) :1251-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
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