L-770644 (dihydrochloride)

L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM) [1].

Product Specifications

CAS Number

[182251-68-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-770644-dihydrochloride.html

Smiles

O=C1N(C2=CC=C(C=C2)S(NC3=CC=C(C=C3)CCNC[C@@H](C4=CN=CC=C4)O)(=O)=O)N=NN1CCCC5CCCC5.Cl.Cl

Molecular Formula

C30H39Cl2N7O4S

Molecular Weight

664.65

References & Citations

[1]Shih TL, et al. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9 (9) :1251-4.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Curated Selection

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