RS-1

RS-1 is a RAD51 activator. RS-1 enhances the homologous recombination activity of human RAD51 by promoting the formation of active presynaptic filaments[1].

Product Specifications

CAS Number

[312756-74-4]

UNSPSC

12352005

Hazard Statement

H319

Target

CRISPR/Cas9; RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RS-1.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2

Molecular Formula

C20H16Br2N2O3S

Molecular Weight

524.23

Precautions

H319

References & Citations

[1]Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105 (41) :15848-53.|[2]Song J, et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548.