Desglymidodrine

Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].

Product Specifications

CAS Number

[3600-87-1]

Product Name Alternative

ST 1059

UNSPSC

12352005

Hazard Statement

H314

Target

Adrenergic Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/desglymidodrine.html

Purity

97.33

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C1=CC(OC)=CC=C1OC)CN

Molecular Formula

C10H15NO3

Molecular Weight

197.23

Precautions

P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

References & Citations

[1]K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22 (2) :215-20.|[2]Steven ABuckner, et al. ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes, European Journal of Pharmacology, Volume 449, Issues 1–2,2002, Pages 159-1