MK-5108

MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC50 value of 0.064 nM.

Product Specifications

CAS Number

[1010085-13-8]

Product Name Alternative

VX-689

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aurora Kinase; Autophagy

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MK-5108.html

Purity

99.60

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(C(Cl)=CC=C1)=C1O[C@H](CC2)CC[C@@]2(C(O)=O)CC3=CC=CC(NC4=NC=CS4)=N3

Molecular Formula

C22H21ClFN3O3S

Molecular Weight

461.94

Precautions

H302, H315, H319, H335

References & Citations

[1]Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9 (1) :157-66.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Aurora A

Available Sizes

Curated Selection

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