MK-5108
MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC50 value of 0.064 nM.
Product Specifications
CAS Number
[1010085-13-8]
Product Name Alternative
VX-689
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aurora Kinase; Autophagy
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-5108.html
Purity
99.60
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C(Cl)=CC=C1)=C1O[C@H](CC2)CC[C@@]2(C(O)=O)CC3=CC=CC(NC4=NC=CS4)=N3
Molecular Formula
C22H21ClFN3O3S
Molecular Weight
461.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9 (1) :157-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Aurora A
Available Sizes
Curated Selection
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